WEBINAR

WGS Without Limits: Powering Clinical Genetics at UMC Utrecht with Callisto™

Tuesday, 7 October 2025
7AM PT | 10AM ET | 4PM CEST

Join us for an in-depth look at how Dr. Bert Van der Zwaag and his team at UMC Utrecht—one of Europe’s leading clinical genomics labs—successfully transitioned from Whole Exome Sequencing (WES) to Whole Genome Sequencing (WGS). Learn how the CallistoTM sample preparation system from Volta Labs enabled their team to unify workflows, reduce turnaround times, and improve operational efficiency in a clinical setting.

This 30-minute session offers a behind-the-scenes view of UMC Utrecht’s evaluation and implementation process; replacing legacy liquid handling systems.

Whether you're considering scaling WGS in your lab or looking to modernize your sample preparation workflows, this webinar offers valuable insights from an experienced clinical genomics team.

🔍 WHAT YOU'LL LEARN:

  • Transitioning to Illumina WGS: UMC Utrecht’s strategy for consolidating diagnostic workflows and their choice of Callisto for sample prep to enable the shift.
  • WGS Library Prep Validation: Technical results from UMC Utrecht’s WGS validation, highlighting Callisto’s high consistency and true walk-away sample processing.
  • Quality Standards: How Callisto was implemented within UMC Utrecht’s ISO 15189-accredited environment, ensuring compliance without disrupting clinical operations.
  • Long-read WGS: Early results and insights from Oxford Nanopore WGS tests on Callisto.

 

PRESENTED BY

Bert

Bert van der Zwaag, PhD.
Clinical Genetic Laboratory, UMC Utrecht

Dr. Bert van der Zwaag has, since 2012, been a registered clinical genetic laboratory specialist at the University Medical Center in Utrecht, the Netherlands. At the ISO15189 accredited genetic diagnostic laboratory, he leads the diagnostic core facility and is focused on the adoption of novel techniques and automations in diagnostic workflows. Recently this has led to the implementation of short read Whole Genome Sequencing to replace Whole Exome Sequencing for NGS based diagnostic testing, yielding the possibility to simultaneously analyze SNV, MNV, CNV and repeat expansions from a single workflow for 10.000 patients on an annual basis. By minimizing the number of individual workflows, diagnostic processing was streamlined and the broad range of patients with suspected genetic disease presenting at UMC Utrecht can be serviced for years to come.

More resources on WGS + Callisto

FOCUS AREA
Whole Genome Sequencing: Learn how Callisto can help scale and deliver high-quality sample prep libraries for your WGS workflow
PRESS RELEASE
UMC Utrecht adopts Volta Labs Callisto Sample Prep System to process thousands of samples for Whole Genome Sequencing-based prenatal and postnatal testing
POSTER
Volta Labs' Digital Fluidics simplifies NGS library prep in a clinical setting